This report presents a security analysis of the 23andMe API endpoints (https://api.23andme.com), conducted to identify potential vulnerabilities that could compromise server integrity and user data. The findings reveal critical issues, including Local File Inclusion (LFI), reflected HTML Injection, and overexposed debug endpoints, which pose significant risks despite existing mitigation measures such as Cloudflare and Content Security Policy (CSP). Although current defenses have prevented immediate exploitation, the underlying lack of sanitization and authentication highlights the need for urgent remediation. With a criticality level assessed at 7 out of 10—reflecting a high impact potential tempered by moderate exploitation probability—these vulnerabilities underscore the importance of proactive security enhancements to protect 23andMe’s systems and millions of users. All findings were responsibly disclosed to 23andMe to facilitate timely resolution.